Aspartame Triggers Insulin Spikes and Inflammation in Blood Vessels

Analysis by Dr. Joseph Mercola

continued from Vol 2 Issue 3 March 2025

Aspartame Alters the Vagus Nerve’s Role in Insulin Regulation

Another shocking revelation from the study is that aspartame influences insulin levels in a completely different way than sugar. In addition, it changes the function of the vagus nerve, which acts as the information highway connecting your gut and brain.

Vagus nerve dysfunction — Instead of raising insulin through a natural glucose response, aspartame stimulates the vagus nerve, which then signals the pancreas to release insulin unnecessarily.14

Insulin sensitivity issues arise — By tricking your body into thinking sugar is present, aspartame creates a hormonal response that your body isn’t designed to handle. Over time, this disrupts insulin sensitivity and leads to metabolic dysfunction, contributing to insulin resistance and increased fat storage.15

Aspartame’s Breakdown Products Exacerbate Health Issues

Beyond its immediate effects on insulin and inflammation, aspartame also breaks down into smaller compounds that contribute to metabolic stress.

Aspartame produces methanol — Methanol, which is an industrial type of alcohol that is used to adulterate liquor,16 has been discovered to be a metabolic byproduct of aspartame digestion. According to a 2021 study, 11% of aspartame turns into pure methanol.17

The impact of methanol — When methanol is metabolized by your body, it turns into formaldehyde, which is known to impact DNAand RNAhealth. Specifically, formaldehyde interacts with basic proteins in the cytosols of your cells, inactivating them. According to the researchers, “such changes have been found in the brains of people suffering from autism.”18

The breakdown of aspartame contributes to long-term health issues by creating additional cellular stress. When combined with aspartame’s inflammatory effects on blood vessels, its overall impact on your body becomes even more apparent, necessitating strategies that repair your cellular health.

Eliminate Aspartame from Your Life to Protect Your Health

As I’ve mentioned in previous articles, aspartame, as well as other artificial sweeteners, will do no good for anyone’s health. It disrupts insulin function, fuels inflammation and even accelerates artery damage. To bring your health back on the right track, the first step is eliminating aspartame while also supporting your metabolism and vascular health. Here are my recommendations:

1. Remove artificial sweeteners from your diet immediately. Aspartame isn’t just in diet sodas. It hides in protein powders, flavored yogurts, sugar-free candies and even some medications. Read labels carefully — if you see products with the words “aspartame,” “acesulfame potassium” or “sucralose,” it’s time to throw them away. Familiarize yourself with other artificial sweeteners as well, such as neotame and sucralose. Instead of artificial sweeteners, choose natural alternatives like raw Manuka honey, maple syrup or coconut sugar in moderation. If you’re trying to transition off sweeteners entirely, fresh fruit is an excellent way to satisfy your cravings while keeping your blood sugar balanced.

2. Heal your insulin sensitivity with targeted carbohydrate intake — If aspartame has already affected your insulin function, the best way to restore balance is to fuel your body with healthy carbohydrates in the right amounts. Aiming for 250 to 300 grams of quality carbs per day — more if you’re physically active — helps prevent the insulin spikes caused by aspartame. Prioritize whole food sources like potatoes, white rice, ripe bananas, and well-cooked vegetables. If your gut health is compromised, start with simple, easily digestible carbs like white rice and whole fruit before introducing more complex starches.

3. Support your gut microbiome for better blood sugar control — Aspartame damages beneficial gut bacteria, which play a direct role in regulating insulin and metabolism. Restoring balance starts with removing harmful foods (vegetable oils, processed meats and artificial additives) and introducing gut-healing food. Fermented foods like sauerkraut, kefir and kimchi provide natural probiotics that help rebalance your microbiome. Collagen-rich bone broth supports the gut lining, and dietary fiber from well-tolerated fruits helps feed beneficial bacteria. As noted in one study, fermented foods helped improve the metabolic health of the participants, including insulin sensitivity and glucose control.19

   
   

4. Reduce hidden sources of inflammation — Inflammation is the link between aspartame, insulin resistance and vascular disease. Cutting artificial sweeteners is just the beginning — you also need to eliminate the biggest dietary sources of inflammation, namely vegetable oils, as they’re high in linoleic acid (LA), an omega-6 polyunsaturated fatty acid. LA drives oxidative stress and worsen insulin resistance. To minimize your intake, I recommend cooking your own food with tallow, grass fed butter and ghee.

   
   

5. Improve cellular energy production with sunlight — Artificial sweeteners disrupt cellular metabolism, but there are still other ways to restore energy production naturally, namely sun exposure. It stimulates mitochondrial function, helping your cells generate ATP (adenosine triphosphate) — the fuel your body runs on.

   
   

Aim for daily morning and midday sunlight, avoiding harsh UV exposure until you’ve been off vegetable oils for at least six months. That’s because when sunlight hits your skin, the LA embedded in it metabolizes, contributing to inflammation and DNAdamage. For a more in-depth explanation on this topic, read my article “Vitamin D Deficiency Complicates Autoimmune Disease.”

Frequently Asked Questions About the Impact of Aspartame on Human Health

Q: How does aspartame affect metabolism if it has no calories?

A: Aspartame stimulates the vagus nerve, tricking your body into Instead of artificial sweeteners, choose natural alternatives like releasing insulin as if sugar were present. Over time, these unnecessary insulin surges lead to insulin resistance, making it harder for your body to regulate blood sugar and increasing the risk of metabolic dysfunction.

Q: Can aspartame cause inflammation in blood vessels?

A: Yes, research shows that aspartame-driven insulin spikes trigger the release of CX3CL1, an inflammatory protein that attracts immune cells to blood vessel walls. This leads to chronic inflammation, artery damage and an increased risk of atherosclerosis.

Q: What are some common foods and drinks that contain aspartame?

A: Aspartame is found in diet sodas, sugar-free gum, flavored yogurts, protein powders, sugar-free candies and even some over-the-counter medications. Checking ingredient labels for "aspartame," "acesulfame potassium," or "sucralose" is key to avoiding it. Beyond aspartame, be sure to avoid other products containing other artificial sweeteners.

Q: If I stop consuming aspartame, how long does it take for my metabolism to recover?

A: Your metabolism starts improving as soon as you remove artificial sweeteners, but full recovery depends on individual factors like the current state of your gut health and the diet you’re eating. Restoring insulin function with targeted carbohydrate intake and healing the gut microbiome with fermented foods will jumpstart the healing process.

Q: What is the best way to naturally regulate blood sugar without artificial sweeteners?

A: Focus on whole-food carbohydrates like potatoes, ripe fruit and white rice to provide steady energy without insulin spikes. Supporting gut health with bone broth and probiotic-rich foods also improves blood sugar control and overall metabolic health.

Sources and References 1, 2, 3, 4, 5, 6, 7, 8, 9 Nutrients. 2022 Oct 22;14(21):4446 10, 11, 12, 13, 14, 15 Cell Metabolism. 2025 May 6;37:1-14 16 Doctors Without Borders, “Methanol Poisoning” 17, 18 Nutrients. 2021 Jun 7;13(6):1957